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Palladium-Catalyzed Synthesis of Aromatic Carboxylic Acids with Silacarboxylic Acids

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journal contribution
posted on 15.03.2013, 00:00 by Stig D. Friis, Thomas L. Andersen, Troels Skrydstrup
Aryl iodides and bromides were easily converted to their corresponding aromatic carboxylic acids via a Pd-catalyzed carbonylation reaction using silacarboxylic acids as an in situ source of carbon monoxide. The reaction conditions were compatible with a wide range of functional groups, and with the aryl iodides, the carbonylation was complete within minutes. The method was adapted to the double and selective isotope labeling of tamibarotene.