American Chemical Society
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Palladium-Catalyzed Synthesis of 9-Fluorenylidenes through Aryne Annulation

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journal contribution
posted on 2009-06-04, 00:00 authored by Shilpa A. Worlikar, Richard C. Larock
The palladium-catalyzed annulation of arynes by substituted o-halostyrenes produces substituted 9-fluorenylidenes in good yields. This methodology provides this important carbocyclic ring system in a single step, which involves the generation of two new carbon−carbon bonds, occurs under relatively mild reaction conditions, and tolerates a variety of functional groups, including cyano, ester, aldehyde, and ketone groups.