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Palladium-Catalyzed Regio- and Stereoselective Hydrosilylation of Electron-Deficient Alkynes

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journal contribution
posted on 16.03.2012, 00:00 by Yuto Sumida, Tomoe Kato, Suguru Yoshida, Takamitsu Hosoya
Highly regio- and stereoselective hydrosilylation applicable to a broad range of electron-deficient alkynes has been established using palladium catalysis. The synthetic utility of the method has been demonstrated by further transformations of α-silylalkenes, particularly Hiyama coupling and stereoinverting iododesilylation followed by Suzuki–Miyaura coupling, which enables stereodivergent syntheses of α-arylenoates.