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Palladium-Catalyzed Oxidative Domino Carbocyclization–Carbonylation–Alkynylation of Enallenes

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journal contribution
posted on 15.08.2014, 00:00 by Chandra M. R. Volla, Jan-E. Bäckvall
An oxidative carbocyclization–carbonylation–alkynylation reaction cascade has been developed using catalytic amounts of palladium­(II) salts. The domino reaction proceeds efficiently, giving the corresponding ynones in good to excellent yields under operationally simple conditions. A wide range of aromatic and aliphatic terminal alkynes with various functional groups are tolerated under the reaction conditions.