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Palladium-Catalyzed One-Pot Synthesis of 2-Alkyl-2-arylcyanoacetates

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journal contribution
posted on 15.02.2008, 00:00 by Xiang Wang, Anil Guram, Emilio Bunel, Guo-Qiang Cao, Jennifer R. Allen, Margaret M. Faul
A one-pot procedure for the synthesis of 2-alkyl-2-arylcyanoacetates based on a Pd(OAc)2/DPPF (DPPF = 1,1‘-diphenylphosphino ferreocene)-catalyzed enolate arylation followed by in situ alkylation has been developed. This procedure tolerates a diverse range of aryl and heteroaryl bromides, and provides a rapid entry to a variety of 2-alkyl-2-arylcyanoacetates in good to excellent yield.