Palladium-Catalyzed Methylation
of Alkynyl C(sp)–H
Bonds with Dimethyl Sulfonium Ylides

Liu, Yan-Yun; Yang, Xu-Heng; Huang, Xiao-Cheng; Wei, Wen-Ting; Song, Ren-Jie; Li, Jin-Heng

doi:10.1021/jo401851m.s001

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Palladium-Catalyzed Methylation of Alkynyl C(sp)–H Bonds with Dimethyl Sulfonium Ylides

journal contribution

posted on 2013-10-18, 00:00 authored by Yan-Yun Liu, Xu-Heng Yang, Xiao-Cheng Huang, Wen-Ting Wei, Ren-Jie Song, Jin-Heng Li

A novel palladium-catalyzed methylation protocol for the synthesis of methyl-functionalized internal alkynes has been established. This methylation method is achieved through a C(sp)–C(sp³) bond formation process and represents a new synthetic application of sulfonium ylides.