American Chemical Society
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Palladium-Catalyzed Methylation of Alkynyl C(sp)–H Bonds with Dimethyl Sulfonium Ylides

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journal contribution
posted on 2013-10-18, 00:00 authored by Yan-Yun Liu, Xu-Heng Yang, Xiao-Cheng Huang, Wen-Ting Wei, Ren-Jie Song, Jin-Heng Li
A novel palladium-catalyzed methylation protocol for the synthesis of methyl-functionalized internal alkynes has been established. This methylation method is achieved through a C­(sp)–C­(sp3) bond formation process and represents a new synthetic application of sulfonium ylides.