American Chemical Society
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Palladium-Catalyzed Intramolecular O-Arylation of Enolates:  Application to Benzo[b]furan Synthesis

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journal contribution
posted on 2004-12-09, 00:00 authored by Michael C. Willis, Dawn Taylor, Adam T. Gillmore
A catalyst generated from Pd2(dba)3 and the ligand DPEphos effects intramolecular C−O bond formation between enolates and aryl halides in the conversion of 1-(2-haloaryl)ketones directly into the corresponding benzofurans. Both cyclic and acyclic ketones are efficient substrates. Thio ketones can also be employed allowing the preparation of the corresponding benzothiophenes.