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Palladium-Catalyzed Direct C–H Arylation of Cyclic Enaminones with Aryl Iodides

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journal contribution
posted on 21.06.2013, 00:00 by Yi-Yun Yu, Lei Bi, Gunda I. Georg
A ligand-free method for the Pd-catalyzed direct arylation of cyclic enaminones using aryl iodides was developed. This method can be applied to a wide range of cyclic enaminones and aryl iodides with excellent C5-regioselectivity. Using widely available aryl iodides, the generality of this transformation provides easy access to a variety of 3-arylpiperidine structural motifs.

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