posted on 2007-02-16, 00:00authored byMiguel A. Pena, José Pérez Sestelo, Luis A. Sarandeses
A range of biaryl compounds (aryl−aryl, aryl−heteroaryl, and heteroaryl−heteroaryl) can be efficiently
prepared by a palladium-catalyzed cross-coupling reaction between ortho-substituted triarylindium reagents
and aryl halides. The triarylindium reagents are prepared by directed ortho-lithiation and transmetallation
to indium from the corresponding benzene derivatives using various directed metallation groups (DMGs).
The reaction proceeds smoothly in high yields and short reaction times with high atom economy (the
three aryl groups attached to indium are efficiently transferred).