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Palladium-Catalyzed β-Allylation of 2,3-Disubstituted Indoles

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journal contribution
posted on 19.06.2008, 00:00 by Natsuko Kagawa, Jeremiah P. Malerich, Viresh H. Rawal
Given the prevalence of the indole nucleus in biologically active compounds, the direct C3-functionalization of 2,3-disubstituted indoles represents an important problem. Described is a general, high-yielding method for the palladium-catalyzed β-allylation of carba- and heterocycle fused indoles, including complex natural product substrates.