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Palladium-Mediated Three-Component Synthesis of Furo[2,3-b]pyridones by One-Pot Coupling of 3-Iodopyridones, Alkynes, and Organic Halides

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journal contribution
posted on 06.06.2003, 00:00 by Emmanuel Bossharth, Philippe Desbordes, Nuno Monteiro, Geneviève Balme
The one-pot assembly of 4-alkoxy-3-iodo-2-pyridones, terminal alkynes, and organic halides has been achieved by integration of two sequential palladium-mediated cross-coupling reactions−Sonogashira and Wacker-type heteroannulation processes−and subsequent deprotection of the alkoxy group to afford furo[2,3-b]pyridones.