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Palladium-Catalyzed Three-Component Reaction: A Novel Method for the Synthesis of N‑Acyl Propiolamides

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journal contribution
posted on 26.10.2018, 13:22 by Yan He, Yingchun Wang, Xinping Liang, Bin Huang, Hengshan Wang, Ying-Ming Pan
Palladium-catalyzed three-component reactions between terminal alkynes, isonitriles, and sodium carboxylates have been developed. This novel and operationally simple methodology provides an alternative for the synthesis of N-acyl propiolamide derivatives under mild conditions using isonitriles as the amine source and sodium carboxylates as the oxygen and acyl source.