Palladium-Catalyzed Site-Selective C–H Arylation of 2,2′-Bipyridine-6-carboxamides via a Rollover Cyclometalation Pathway

The first example of Pd­(II)-catalyzed arylation of 2,2′-bipyridine-6-carboxamides via a rollover cyclometalation pathway is reported. A diverse range of (hetero)­aryl iodides could be directly coupled with various 2,2′-bipyridine-6-carboxamides in exclusive site-selectivity, which offers a distinct entry to arylated 2,2′-bipyridine-6-carboxamides. A preliminary mechanistic study supports the Pd­(II)-rollover cyclometalation pathway.