American Chemical Society
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Palladium-Catalyzed Selective [2 + 2 + 2] Annulation of 2‑(2-Enynyl)pyridines with Arynes

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journal contribution
posted on 2021-08-11, 20:31 authored by Zongli Xiong, Jingxiang Duan, Xiaoyi Li, Xin Wang, Yesu Addepalli, Mengxue Lu, Weijun Yao, Ling He, Zhen Wang
The palladium-catalyzed chemo- and stereoselective [2 + 2 + 2] annulation reaction of 2-(2-enynyl)­pyridines with arynes has been developed. A wide range of (E)- or (E/Z)-isomers of 2-(2-enynyl)­pyridines and arynes was tolerated, providing a spectrum of (E)-phenanthrenylated 2-alkenylpyridines in good yield, together with the generation of a chiral axis between an alkene and a phenanthrene ring.