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Palladium-Catalyzed Regioselective Olefination of O‑Acetyl Cyanohydrins

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journal contribution
posted on 14.06.2018, 00:00 by Qiu-Ju Liang, Bing Jiang, Yun-He Xu, Teck-Peng Loh
A practical palladium-catalyzed ortho-olefination of O-acetyl cyanohydrins assisted by synergetic directing groups has been developed. Thus, a range of olefinated O-acetyl cyanohydrins were synthesized in moderate to good yields. The reaction occurs efficiently with high regioselectivity and with a satisfactory tolerance of functional groups.