Palladium-Catalyzed Multicomponent Synthesis of Fully Substituted Alkylidene Furanones

In the presence of a catalytic amount of Pd­(OAc)₂ and XantPhos, the three-component reaction of ynones, imines, and aryl iodides affords fully substituted alkylidene-furan-3­(2H)-ones via a sequence of the Mannich reaction followed by chemo- and regioselective oxypalladation and reductive elimination. One carbon–oxygen and two carbon–carbon bonds are generated to afford the heterocycle in good to excellent yield.