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Palladium-Catalyzed Intermolecular Hydroamination of Alkynes:  A Dramatic Rate-Enhancement Effect of o-Aminophenol

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journal contribution
posted on 02.10.2002, 00:00 by Tomohiro Shimada, Yoshinori Yamamoto
The hydroamination of alkynes using o-aminophenol proceeds in very high to good yields in the presence of Pd(NO3)2 catalyst. Remarkable rate enhancement with o-aminophenol is presumably due to the chelation effect of the ortho OH group to palladium.