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Download filePalladium-Catalyzed Cascade Decarboxylative Amination/6-endo-dig Benzannulation of o‑Alkynylarylketones with N‑Hydroxyamides To Access Diverse 1‑Naphthylamine Derivatives
journal contribution
posted on 2020-05-04, 11:35 authored by Youpeng Zuo, Xinwei He, Qiang Tang, Wangcheng Hu, Tongtong Zhou, Yongjia ShangAn efficient and practical one-pot
strategy to produce highly substituted
1-naphthylamines via sequential palladium-catalyzed decarboxylative
amination/intramolecular 6-endo-dig benzannulation
reactions has been described. In this reaction, a broad range of electron-rich,
electron-neutral, and electron-deficient o-alkynylarylketones
react well with N-hydroxyl aryl/alkylamides to give
a diversity of 1-naphthylamines in good to excellent yields under
mild reaction conditions. The gram-scale synthesis, with benefits
such as undiminished product yield and easy transformation, illustrated
the practicality of this method.
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benefitreaction conditionsendo-dig6-Palladium-CatalyzedHydroxyamideDecarboxylativeBenzannulationDerivativeAlkynylarylketoneelectron-neutralelectron-deficientmethodAminationbenzannulationdecarboxylativealkynylarylketoneone-pot strategygram-scale synthesiselectron-richsequentialyieldCascadeaminationNaphthylamineAccesspalladium-catalyzed1- naphthylaminespracticalitydiversitytransformationDiversearylhydroxyl