Palladium-Catalyzed Carbonylative Synthesis of Polycyclic 3,4-Dihydroquinolin-2(1<i>H</i>)‑one Scaffolds Containing Perfluoroalkyl and Carbonyl Units

A palladium-catalyzed one-pot two-step radical mediated carbonylative cyclization of 1,7-enynes with perfluoroalkyl iodides and Mo­(CO)₆ has been developed for the construction of polycyclic 3,4-dihydroquinolin-2­(1<i>H</i>)-one scaffolds. This method realizes a facile synthesis of various polycyclic 3,4-dihydroquinolin-2­(1<i>H</i>)-one derivatives containing perfluoroalkyl and carbonyl units in high yields. Moreover, modifications of several bioactive molecules were demonstrated using this protocol.