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Palladium-Catalyzed C–N Cross-Coupling of NH-Heteroarenes and Quaternary Ammonium Salts via C–N Bond Cleavage

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journal contribution
posted on 2019-08-02, 19:36 authored by Hongyi Chen, Hongqin Yang, Nutao Li, Xinghua Xue, Ze He, Qingle Zeng
In this paper, we extend the substrate class of Buchwald–Hartwig amination to quaternary ammonium salts. In the presence of Pd­(OAc)2 and t-BuXPhos, the coupling of aryl- or arylmethyltrimethylammonium triflates with NH-heteroarenes via C–N bond cleavage affords the desired N-aryl or N-arylmethyl heteroarenes in moderate to excellent yields.