American Chemical Society
ol2c04017_si_001.pdf (8.69 MB)

Palladium-Catalyzed Asymmetric C–C Bond Activation/Carbonylation of Cyclobutanones

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journal contribution
posted on 2022-12-05, 19:10 authored by Long Chen, Cong Shi, Wei Li, Bo Li, Jie Zhu, Aijun Lin, Hequan Yao
A palladium-catalyzed asymmetric C–C bond activation/carbonylation of cyclobutanones with CO has been developed. This reaction provided an efficient method for the synthesis of chiral indanones bearing a quaternary carbon stereocenter in good yields with an excellent enantiomeric ratio, exhibiting good functional group tolerance. Transformations of the products to chiral 3,4-dihydroquinolin-2(1H)-one and 1H-indene further demonstrated the versatility of this reaction.