Palladium-Catalyzed Asymmetric C–C Bond Activation/Carbonylation of Cyclobutanones
journal contribution
posted on 2022-12-05, 19:10 authored by Long Chen, Cong Shi, Wei Li, Bo Li, Jie Zhu, Aijun Lin, Hequan YaoA palladium-catalyzed asymmetric C–C bond activation/carbonylation
of cyclobutanones with CO has been developed. This reaction provided
an efficient method for the synthesis of chiral indanones bearing
a quaternary carbon stereocenter in good yields with an excellent
enantiomeric ratio, exhibiting good functional group tolerance. Transformations
of the products to chiral 3,4-dihydroquinolin-2(1H)-one and 1H-indene further demonstrated the versatility
of this reaction.
