ol6b03130_si_001.pdf (765.74 kB)

Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes

Download (765.74 kB)
journal contribution
posted on 22.11.2016, 14:22 by Chuanhu Lei, Jiajia Cao, Jianrong (Steve) Zhou
Palladium-catalyzed α-arylation reactions of ketones with simultaneous ortho alkylation offer 1,2,3-substituted arenes. The reactions of 1,ω-dihaloalkanes also allow facile construction of medicinally important tetralines and benzocycloheptenes.