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Download filePalladium-Catalyzed Aerobic Oxidative Kinetic Resolution of Alcohols with an Achiral Exogenous Base
journal contribution
posted on 2003-08-22, 00:00 authored by Sunil K. Mandal, Matthew S. SigmanSubstitution of exogenous (−)-sparteine for a
more practical achiral base in the aerobic oxidative kinetic
resolution of secondary alcohols is described. Carbonate
bases are the most effective of those screened and allow for
effective kinetic resolution of benzylic, allylic, and aliphatic
substrates. The procedure was also successfully extended
to the oxidative desymmetrization of meso diols.