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Palladium-Catalyzed 6‑Endo Selective Alkyl-Heck Reactions: Access to 5‑Phenyl-1,2,3,6-tetrahydro­pyridine Derivatives

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journal contribution
posted on 13.07.2016, 00:00 by Xu Dong, Ying Han, Fachao Yan, Qing Liu, Ping Wang, Kexun Chen, Yueyun Li, Zengdian Zhao, Yunhui Dong, Hui Liu
A new type of palladium-catalyzed 6-endo-selective alkyl-Heck reaction of unactivated alkyl iodides has been described. This strategy provides efficient access to a variety of 5-phenyl-1,2,3,6-tetrahydropyridine derivatives, which are important structural motifs for bioactive molecules. This process displays a broad substrate scope with excellent 6-endo selectivity. Mechanistic investigations reveal that this alkyl-Heck reaction performs via a hybrid palladium-radical process.