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P(RNCH2CH2)3N-Catalyzed Synthesis of β-Hydroxy Nitriles

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journal contribution
posted on 09.04.1999, 00:00 by Philip Kisanga, Dale McLeod, Bosco D'S, John Verkade
We herein report the successful synthesis of β-hydroxy nitriles in very good to excellent yields from aldehydes and ketones in a simple reaction that is promoted by strong nonionic bases of the title type. The reaction occurs in the presence of magnesium salts which activate the carbonyl group and stabilizes the enolate thus produced.