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P‑Chiral Monophosphorus Ligands for Asymmetric Copper-Catalyzed Allylic Alkylation

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journal contribution
posted on 07.06.2019, 18:04 by Wenrui Xiong, Guangqing Xu, Xinhong Yu, Wenjun Tang
Asymmetric copper-catalyzed allylic alkylation between allyl bromides and alkyl Grignard reagents using a P-chiral monophosphorus ligand is described. A range of terminal olefins bearing tertiary or quaternary carbon centers were formed in good branched/linear selectivities and excellent enantioselectivities at copper loadings as low as 0.5 mol %.