American Chemical Society
ol8b03018_si_002.pdf (3.45 MB)

PPh3AuTFA Catalyzed in the Dearomatization of 2‑Naphthols with Allenamides

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journal contribution
posted on 2018-11-12, 12:50 authored by Juzeng An, Lorenzo Lombardi, Stefano Grilli, Marco Bandini
A new catalytic methodology for the direct dearomatization of substituted 2-naphthols via intermolecular condensation with allenamides is presented. PPh3AuTFA (5 mol %) promotes the formal allylating dearomative protocol under mild conditions, large scope (24 examples), and high regioselectivity and stereoselectivity. The synergistic catalytic role played by the [PPh3Au]+ (π-acid) and TFA (Lewis base) is highlighted.