ol400604e_si_001.pdf (686.92 kB)

Oxidative para-Triflation of Acetanilides

Download (686.92 kB)
journal contribution
posted on 05.04.2013, 00:00 by Amélie Pialat, Benoît Liégault, Marc Taillefer
Direct triflation of acetanilide derivatives with silver triflate has been accomplished under mild iodine(III)-mediated oxidative conditions. The reaction shows excellent regioselectivity for the para position and tolerates a range of ortho and meta substituents on the aromatic ring. This method is also compatible with the preparation of arylnonaflates in synthetically useful yields.

History