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Oxidative Radical Addition–Cyclization of Sulfonyl Hydrazones with Simple Olefins by Binary Acid Catalysis

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journal contribution
posted on 15.06.2016, 17:36 by Xingren Zhong, Jian Lv, Sanzhong Luo
An unprecedented binary acid accelerated oxidative radical annulation of sulfonyl hydrazones with simple olefins is described. Notably, this method provides a novel oxidative radical cycloaddition for the construction of six-member heterocycles. It offers a rapid and efficient approach to tetrahydro­pyridazines which are key structural motifs in pharmaceutically active compounds.