posted on 2021-01-25, 15:33authored bySatish
G. More, Rohit B. Kamble, Gurunath Suryavanshi
The
highly regioselective synthesis of substituted hemiaminal via addition of ethers to quinone imine ketals (QIKs) has
been developed under metal-free conditions. In the presence of tetrabutylammonium
chloride and potassium persulfate (K2S2O8), QIKs couple efficiently with cyclic and acyclic ethers
to give hemiaminals. This strategy offers an easy access to substituted
hemiaminal ethers with high functional group tolerance in good to
excellent yields.