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Oxidative Difunctionalization of Alkynoates through Alkylation and Migration Decarboxylative Arylation

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journal contribution
posted on 20.11.2015, 00:00 by Shengyang Ni, Yu Zhang, Chen Xie, Haibo Mei, Jianlin Han, Yi Pan
A cascade oxidative difunctionalization reaction of alkynoates for the construction of trisubstituted olefins has been developed. The process undergoes alkylation of a C–C triple bond, 1,4-aryl migration, and decarboxylation, which demonstrates a multistep radical cascade reaction for the difunctionalization of alkynoates and also represents a strategy of direct decarboxylation of esters.