ol051296m_si_001.pdf (249.79 kB)
Oxidative Cyclization Reactions: Amide Trapping Groups and the Synthesis of Furanones
journal contribution
posted on 2005-08-04, 00:00 authored by John D. Brandt, Kevin D. MoellerIntramolecular anodic coupling reactions involving ketene dithioacetal radical cations and amide trapping groups have been examined. The
reactions generate furanone products and benefit greatly from the addition of water to the reaction medium. The cyclization reactions lead to
products having stereochemistry that is directly analogous to oxidative cyclization reactions utilizing ketene dithioiacetal radical cations and
alcohol trapping groups.