Oxidative Alkenylation of Aromatic Esters by Ruthenium-Catalyzed Twofold C–H Bond Cleavages
journal contributionposted on 20.02.2016, 14:21 by Karolina Graczyk, Wenbo Ma, Lutz Ackermann
Cationic ruthenium(II) complexes enabled catalytic twofold C–H bond functionalizations with weakly coordinating aromatic esters in a highly chemo-, site- and diastereo-selective as well as site selective fashion. The oxidative Fujiwara–Moritani-type alkenylation provided step-economical access to diversely substituted styrenes and proved viable in an aerobic manner. Mechanistic studies were indicative of a reversible acetate-assisted cycloruthenation step.