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Oxidation of Tetrahydro-β-carbolines by Persulfate

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journal contribution
posted on 06.09.2019, 13:03 by Haijun Chen, Fu Ye, Jing Luo, Yu Gao
The development of persulfate-mediated oxidation of tetrahydro-β-carbolines is reported. This mild reaction facilitates the formation of a variety of 2-formyl N-substituted tryptamines and the related derivatives as key intermediates in moderate to excellent yields. The method is applicable to direct last-stage oxidation of two interesting pharmaceuticals, Cialis and evodiamine.