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Overcoming the Naphthyl Requirement in Stereospecific Cross-Couplings to Form Quaternary Stereocenters

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journal contribution
posted on 01.06.2021, 21:30 authored by Jianyu Xu, Olivia P. Bercher, Mary P. Watson
The use of a simple stilbene ligand has enabled a stereospecific Suzuki–Miyaura cross-coupling of tertiary benzylic carboxylates, including those lacking naphthyl substituents. This method installs challenging all-carbon diaryl quaternary stereocenters in good yield and ee and represents an important breakthrough in the “naphthyl requirement” that pervades stereospecific cross-couplings involving enantioenriched electrophiles.