ol5b00213_si_001.pdf (3.28 MB)
Download fileOrganoselenium-Catalyzed, Hydroxy-Controlled Regio- and Stereoselective Amination of Terminal Alkenes: Efficient Synthesis of 3‑Amino Allylic Alcohols
journal contribution
posted on 17.04.2015, 00:00 authored by Zhimin Deng, Jialiang Wei, Lihao Liao, Haiyan Huang, Xiaodan ZhaoAn
efficient route to prepare 3-amino allylic alcohols in excellent regio-
and stereoselectivity in the presence of bases by orangoselenium catalysis
has been developed. In the absence of bases α,β-unsaturated
aldehydes were formed in up to 97% yield. Control experiments reveal
that the hydroxy group is crucial for the direct amination.