jo502254e_si_001.pdf (5.13 MB)
Organocatalyzed Asymmetric Aldol Reactions of Ketones and β,γ‑Unsaturated α‑Ketoesters and Phenylglyoxal Hydrates
journal contribution
posted on 2015-01-16, 00:00 authored by Swapna Konda, Qun-Sheng Guo, Manabu Abe, Huicai Huang, Hadi Arman, John C.-G. ZhaoEnantioselective
aldol reactions of acetophenone with β,γ-unsaturated
α-ketoesters and cyclic ketones with phenylglyoxal hydrates
were realized with cinchona alkaloid-derived thiourea catalysts. The
corresponding aldol products were obtained in high yields and good
to excellent diastereoselectivities and enantioselectivities (up to
95% ee).