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Organocatalytic and Highly Enantioselective Direct α-Amination of Aromatic Ketones

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journal contribution
posted on 30.08.2007, 00:00 authored by Tian-Yu Liu, Hai-Lei Cui, Yan Zhang, Kun Jiang, Wei Du, Zhao-Quan He, Ying-Chun Chen
The first highly enantioselective direct α-amination of aryl ketones was reported to be catalyzed by organic primary amines derived from cinchona alkaloids. Excellent enantioselectivities (88−99% ee) have been achieved for a broad spectrum of aryl ketones. The presence of 4 Å molecular sieves was of great assistance for the high conversions and enantiocontrol.

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