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Organocatalytic Sequential α-Amination−Horner−Wadsworth−Emmons Olefination of Aldehydes:  Enantioselective Synthesis of γ-Amino-α,β-Unsaturated Esters

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journal contribution
posted on 15.03.2007, 00:00 by Shriram P. Kotkar, Vilas B. Chavan, Arumugam Sudalai
A novel and highly enantioselective method for the synthesis of γ-amino-α,β-unsaturated esters via tandem α-amination−Horner−Wadsworth−Emmons (HWE) olefination of aldehydes is described. The one-pot assembly has been demonstrated for the construction of functionalized chiral 2-pyrrolidones, subunits present in several alkaloids.