Organocatalytic Enantioselective Cross-Aldol Reaction of o‑Hydroxyarylketones and Trifluoromethyl Ketones
journal contributionposted on 08.05.2017, 15:14 authored by Pei Wang, Hong-Feng Li, Jia-Zhen Zhao, Zhi-Hong Du, Chao-Shan Da
The enantioselective cross-aldol reaction between o-hydroxyacetophenones and trifluoromethyl ketones catalyzed by chiral thiourea organocatalysts is reported. Gram-scale synthesis of the cross-aldol product was carried out, with no decrease in the yield and enantioselectivity. Furthermore, the cross-aldol products thus prepared were used in the preparation of medicinally interesting 3,5-diaryl-5-trifluoromethyl-2-isoxazoline and β-trifluoromethyl-β-tertiary hydroxy acid ester with high yield and enantiopurity.