ol503309s_si_001.pdf (13.65 MB)
Organocatalytic Enantioselective Addition of Thiols to Ketimines Derived from Isatins
journal contribution
posted on 2015-01-02, 00:00 authored by Shuichi Nakamura, Shun Takahashi, Daisuke Nakane, Hideki MasudaThe
first catalytic enantioselective addition of thiols to ketimines
derived from isatins has been developed. Excellent yields and enantioselectivities
were observed for the reaction of various ketimines and thiols using
a cinchona alkaloid sulfonamide catalyst. Both enantiomers of products
could be obtained by using pseudoenantiomeric chiral catalysts.