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Organocatalytic Conjugate Addition of Formaldehyde N,N-Dialkylhydrazones to β,γ-Unsaturated α-Keto Esters

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journal contribution
posted on 16.08.2007, 00:00 by Raquel P. Herrera, David Monge, Eloísa Martín-Zamora, Rosario Fernández, José M. Lassaletta
(1S,2R)-1-Aminoindan-2-ol-derived thioureas behave as efficient H-bonding organocatalysts for the nucleophilic conjugate addition of formaldehyde hydrazones to β,γ-unsaturated α-keto esters as enoate surrogates, affording the corresponding adducts in good yields and enantioselectivities.