American Chemical Society
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Organocatalytic Atroposelective Formal Diels–Alder Desymmetrization of N‑Arylmaleimides

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journal contribution
posted on 2015-04-03, 00:00 authored by Florine Eudier, Paolo Righi, Andrea Mazzanti, Alessia Ciogli, Giorgio Bencivenni
The atroposelective desymmetrization of N-arylmaleimides was realized by means of a primary amine catalyzed Diels–Alder reaction of enones. The chiral axis as new element of chirality is generated under the remote control of the catalyst that selectively drives the formal Diels–Alder reaction through an exclusive stereochemical outcome.