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Organocatalytic Asymmetric Synthesis of Bridged Acetals with Spirooxindole Skeleton

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journal contribution
posted on 29.10.2018, 00:00 by Megha Balha, Subhas Chandra Pan
The first highly diastereo- and enantioselective synthesis of bridged O,O-acetals embedded with spirooxindoles has been developed. Dioxindoles and 2-hydroxy cinnamaldehydes were employed as the reaction partners in this method. The desired products were obtained via diaryl prolinol TBS ether catalyzed Michael reaction followed by acetal formation with TFA.