Oral Administration of Starting Materials for In Vivo Synthesis of Antibacterial Gold Nanoparticles for Curing Remote Infections
journal contributionposted on 16.01.2021, 18:13 by Le Wang, Junchuan Yang, Sixiang Li, Qizhen Li, Shaoqin Liu, Wenfu Zheng, Xingyu Jiang
Oral administration is a facile and safe way for medication. However, most of the reported nanomedicines could not be taken orally, partially due to their unsatisfied stability, poor absorbance, or toxicity in the gastrointestinal tract. Here, we demonstrate that we could robustly synthesize gold nanoparticles (GNPs) in vivo by orally administering two starting materials, tetrachloroauric acid and aminophenyl boronic acid (ABA). The ABA-activated GNPs (A-GNPs) synthesized in vivo could be absorbed by the gastrointestinal tract and reach the remote infection lesions such as peritonitis caused by multidrug resistant (MDR) bacteria in mice. The A-GNPs exhibit excellent antibacterial efficacy (MIC, 3 μg/mL), long half-life (16–17 h), effective clearance (residual concentration is near 0 within 72 h), and high biosafety (safe dose/effective dose, 8 times). Our study is a pioneering attempt for synthesizing and taking nanomedicines orally just like preparing and drinking a cocktail.
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medicationbiosafetynanomedicineMICdosestabilitygold nanoparticlesAntibacterial Gold NanoparticlesABA-activated GNPsOral AdministrationMaterialA-GNPs exhibitMDRtetrachloroauric acidefficacymaterialmultidrugperitonitisynthesizingdrinkingVivo Synthesistractabsorbance8 timesinfection lesionsclearanceCuring Remote Infections Oral admin...half-lifevivoconcentrationtoxicityaminophenyl boronic acid