posted on 2020-04-03, 13:19authored byTsung-Han (Calvin) Yang, Chanel K. Yee, Meri L. Amweg, Seema Singh, Eric L. Kendall, Andrew M. Dattelbaum, Andrew P. Shreve, C. Jeffrey Brinker, Atul N. Parikh
The integration of ion-channel transport functions with responses derived from nanostructured and nanoporous silica mesophase materials
is demonstrated. Patterned thin-film mesophases consisting of alternating hydrophilic nanoporous regions and hydrophobic nanostructured
regions allow for spatially localized proton transport via selective dimerization of gramicidin in lipid bilayers formed on the hydrophilic regions.
The adjoining hydrophobic mesostructure doped with a pH sensitive dye reports the transport. The ease of integrating functional membranes
and reporters through the use of patterned mesophases should enable high throughput studies of membrane transport.