ol060430f_si_001.pdf (988.09 kB)
Operationally Simple, Efficient, and Diastereoselective Synthesis of cis-2,6-Disubstituted-4-Methylene Tetrahydropyrans Catalyzed by Triflic Acid
journal contribution
posted on 2006-04-27, 00:00 authored by Alessandra Puglisi, Ai-Lan Lee, Richard R. Schrock, Amir H. HoveydaA highly efficient (0.01 mol % of TfOH), operationally simple (room temperature, inexpensive, and commercially available catalyst), and
diastereoselective (up to >98% de) method for Brønsted acid-catalyzed reaction of enol ethers to form cis-2,6-disubstituted tetrahydropyrans
is disclosed.