One-Step Synthesis of Nanoscale Zeolitic Imidazolate Frameworks with High Curcumin Loading for Treatment of Cervical Cancer
journal contributionposted on 14.10.2015, 00:00 by Min Zheng, Shi Liu, Xingang Guan, Zhigang Xie
A straightforward nanoprecipitating method was developed to prepare water dispersible curcumin (CCM)-loaded nanoscale zeolitic imidazolate framework-8 (CCM@NZIF-8) nanoparticles (NPs). The as-synthesized CCM@NZIF-8 NPs possess high drug encapsulation efficiency (88.2%), good chemical stability and fast drug release in tumor acidic microenvironments. Confocal laser scanning microscopy and cytotoxicity experiments reveal that NZIF-8 based nanocarriers promote the cellular uptake of CCM and result in higher cytotoxicity of CCM@NZIF-8 than that of free CCM toward HeLa cells. The in vivo anticancer experiments indicate that CCM@NZIF-8 NPs exhibit much higher antitumor efficacy than free CCM. This work highlights the potential of using nanoscale metal organic framworks (NMOFs) as a simple and stable platform for developing a highly efficient drug delivery system in cancer treatment.
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Cervical CancerACCMchemical stabilitydrug releasenanoprecipitating methodvivo anticancer experimentsHigh Curcumin Loadingnanoscale metalNMOFNanoscale Zeolitic Imidazolate FrameworksHeLa cellstumor acidic microenvironmentsNPcytotoxicity experimentsdrug delivery systemNZIFantitumor efficacycancer treatmentConfocal laser scanning microscopywater dispersible curcumin