American Chemical Society
ol0629667_si_001.pdf (1.34 MB)

One-Step Synthesis of α-Chloro Acetophenones from Acid Chlorides and Aryl Precursors

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journal contribution
posted on 2007-02-15, 00:00 authored by Jonathan Rosen, Dietrich Steinhuebel, Michael Palucki, Ian Davies
A direct and efficient method was developed for the preparation of a variety of substituted acetophenone derivatives from readily available arene precursors and acid chlorides. This method has significant generality and affords access to substitution patterns on aryl rings not directly achievable by Friedel−Crafts chemistry.