American Chemical Society
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One-Pot Transformation of Trichloroacetamide into Readily Deprotectable Carbamates

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journal contribution
posted on 2006-07-20, 00:00 authored by Toshio Nishikawa, Daisuke Urabe, Miho Tomita, Takashi Tsujimoto, Tomoko Iwabuchi, Minoru Isobe
A trichloroacetamide group was converted to an isocyanate, which was in situ captured by a variety of alcohols in the presence of CuCl and n-BuN4Cl to afford the corresponding carbamates. The scope and limitation of this transformation are also described.