One-Pot Transformation of
Trichloroacetamide into Readily
Deprotectable Carbamates

Nishikawa, Toshio; Urabe, Daisuke; Tomita, Miho; Tsujimoto, Takashi; Iwabuchi, Tomoko; Isobe, Minoru

doi:10.1021/ol061123c.s001

ol061123c_si_001.pdf (177.94 kB)

One-Pot Transformation of Trichloroacetamide into Readily Deprotectable Carbamates

journal contribution

posted on 2006-07-20, 00:00 authored by Toshio Nishikawa, Daisuke Urabe, Miho Tomita, Takashi Tsujimoto, Tomoko Iwabuchi, Minoru Isobe

A trichloroacetamide group was converted to an isocyanate, which was in situ captured by a variety of alcohols in the presence of CuCl and n-BuN₄Cl to afford the corresponding carbamates. The scope and limitation of this transformation are also described.